Work

A somatic mutation of RasGRP3 decreases Na+/I- symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.

Year: 2018

Type: article

Abstract: is a more frequent genetic alteration in metastases of RAI-refractory differentiated thyroid cancer. This mutant RasGRP3 activated the Akt pathway, promoted thyroid cancer cell proliferation and invasion, and reduced NIS expression and the iodine uptake ability.

Source: Europe PMC (PubMed Central)

Authors: Jianlu Song, Wangwang Qiu, Xianzhao Deng, Zhongling Qiu, Youben Fan, Zhili Yang

Institutions: Shanghai Jiao Tong University, Shanghai Sixth People's Hospital

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2996562370

FWCI: 1.091

Cites: 23

Cited by: 10

Related to: 10