Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART)
Year: 2019
Type: article
Study design: Observational Study
Abstract: Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFTs). Recently, primary age-related tauopathy (PART) has been described as a new anatomopathological disorder where NFTs are the main feature in the absence of neuritic plaques. However, since PART has mainly been studied in post-mortem patient brains, not much is known about the clinical or neuroimaging characteristics of PART. Here, we studied the clinical brain imaging characteristics of PART focusing on neuroanatomical vulnerability by applying a previously validated multiregion visual atrophy scale. We analysed 26 cases with confirmed PART with paired clinical magnetic resonance imaging (MRI) acquisitions. In this selected cohort we found that upon correcting for the effect of age, there is increased atrophy in the medial temporal region with increasing Braak staging (r = 0.3937, p = 0.0466). Upon controlling for Braak staging effect, predominantly two regions, anterior temporal (r = 0.3638, p = 0.0677) and medial temporal (r = 0.3836, p = 0.053), show a trend for increased atrophy with increasing age. Moreover, anterior temporal lobe atrophy was associated with decreased semantic memory/language (r = - 0.5823, p = 0.0056; and r = - 0.6371, p = 0.0019, respectively), as was medial temporal lobe atrophy (r = - 0.4445, p = 0.0435). Overall, these findings support that PART is associated with medial temporal lobe atrophy and predominantly affects semantic memory/language. These findings highlight that other factors associated with aging and beyond NFTs could be involved in PART pathophysiology.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,290
Awards: G1075639496, G1104192986, G1106781614, G113062254, G1171648585, G1173778324, G1263262031, Michigan Alzheimer's Disease Core Center, UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, G1369195717, G1375833519, G1492531059, G1663213784, G1711016037, Wake Forest Alzheimer's Disease Core Center, G2075747288, G234895681, G2382900055, University of Kentucky Alzheimer's Disease Core Center, Neurobiology of Alzheimer's Disease and Aging, G2640555407, G2769554943, G282710236, G2929235049, G3026342146, G3066742295, Alzheimer's Disease Research Center, G3218891203, National Alzheimer's Coordinating Center, G3335858628, G3359100610, G3439557519, Alzheimer's Disease Research Center, Regulation of tau expression in Alzheimer disease and aging, G3818147302, G3876327265, G3946457848, G4082276054, G4103239427, Alzheimer's Disease Core Center, G4318823550, The Alzheimer's Disease Research Center at the University of California, Irvine, Stanford Alzheimer's Disease Research Center, G4684857399, G469773307, G4874008555, Oregon Alzheimer's Disease Center, G4968636904, Rush Alzheimer's Disease Core Center, Age-related Tauopathy in HIV-associated Neurocognitive Disorders, Alzheimer's Disease Core Center, Alzheimer's Disease Research Center - Overall, G639043084, G6445626367, G6492025387, University of Kansas Alzheimer's Disease Core Centers, The Contribution of Age-Related Tauopathies to Alzheimer's Disease, G6750444795, G6876577119, Alzheimer's Disease Research Center, Alzheimer Disease Research Center, Yale Alzheimer Disease Research Center, G7042289108, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, G7176475171, G7409097460, G7576515556, Boston University Alzheimer's Disease Center, Alzheimer's Disease Research Center, G76412088, Alzheimer's Disease Core Center, G8018240826, Emory Alzheimer's Disease Center, University of Florida - Mt. Sinai Medical Center AD Research Center, G8620018032, G873702183, G9000000175, G9000013408, G9000025891, G9000030076, G9000033698, G9000036492, G9000043956, G9000064269, G9000070217, G9000104082, G9000108235, G9000119544, G9000126115, G9000132673, G9000145746, G9000167101, G9000193634, G9000212151, G9000218452, G9000218858, G9000227227, G9000227779, G9000252716, G9000274623, G9000307348, G9000332211, G9000354213, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, New Approaches to Dementia Heterogeneity, Wisconsin Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, Mechanisms of age-related tauopathy, Massachusetts Alzheimer's Disease Research Center (MADRC), New Approaches to Dementia Heterogeneity
OpenAlex ID: W2996573401