Work

Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase

Year: 2019

Type: article

Abstract: (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.

Source: RSC Medicinal Chemistry

DOI: 10.1039/c9md00511k

Authors: Shams Ul Mahmood, Huimin Cheng, Sreedhar R. Tummalapalli, Ramappa Chakrasali, Rammohan R. Yadav Bheemanaboina, Tamara Kreiss, Agnieska Chojnowski, Tyler Eck, John J. Siekierka, David P. Rotella

Institution: Montclair State University

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Margaret and Herman Sokol Institute for Pharmaceutical Life Sciences, Montclair State University, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G4962150376, G9000344262

OpenAlex ID: W2996597155

FWCI: 1.881

Cites: 12

Cited by: 11

Related to: 10