Work

UPR ER promotes lipophagy independent of chaperones to extend life span

Year: 2020

Type: article

Abstract: , is sufficient to deplete lipids, remodel ER, and promote life span. Therefore, UPR induction in neurons triggers two distinct programs in the periphery: the proteostasis arm through protein chaperones and metabolic changes through lipid depletion mediated by EH domain binding protein 1 (EHBP-1).

Source: Science Advances

DOI: 10.1126/sciadv.aaz1441

Authors: Joseph R. Daniele, Ryo Higuchi-Sanabria, Jenni Durieux, Samira Monshietehadi, Vidhya Ramachandran, Sarah U. Tronnes, Naame Kelet, Melissa Sanchez, Melissa G. Metcalf, Gilberto Garcia, Phillip A. Frankino, Camila Benitez, Mandy Zeng, Daniel J. Esping, Larry Joe, Andrew Dillin

Institutions: Howard Hughes Medical Institute, University of California, Berkeley, Thermo Fisher Scientific (United States), University of Minnesota

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: Howard Hughes Medical Institute, Glenn Foundation for Medical Research, National Institute on Aging

Awards: G2621618881, G4119178126, G4510567480

OpenAlex ID: W2996802429

FWCI: 4.01

Cites: 38

Cited by: 78

Related to: 10