Work

A metal-free aromatic cascade for the synthesis of diverse heterocycles

Year: 2020

Type: article

Abstract: A metal-free aromative cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade being by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6π-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.

Source: Organic Chemistry Frontiers

DOI: 10.1039/c9qo01336a

Authors: Steven C. Schlitzer, Dhanarajan Arunprasath, Katelyn G. Stevens, Indrajeet Sharma

Institution: University of Oklahoma

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: American Chemical Society Petroleum Research Fund, National Institute of General Medical Sciences, Division of Chemistry

Awards: G2352090308, G2743450784, Oklahoma COBRE in Structural Biology