Work

Advances on the Metabolism of Cohesin in Age-Related Chromosomal Aneuploidy

Year: 2019

Type: article

Abstract: Age-related chromosomal aneuploidy is associated with the reduction of cohesin in meiosis. There are many complicated factors affecting the metabolism of cohesion, including the hyperactive separase, abnormal Shugoshin protein degradation, oxidative damage, increased intracellular pH in oocytes, abnormal metabolism of spindle assembly checkpoint, anaphase-promoting complex, and age-related reproductive hormones, which are summarized in the review.

Source: Reproductive and Developmental Medicine

DOI: 10.4103/2096-2924.274547

Authors: Li-Yuan Tian, Bin Zhang

Institutions: Obstetrics and Gynecology Hospital of Fudan University, Shanghai Medical College of Fudan University, Fudan University

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2996920122