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The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies

Year: 2019
Type: review
Abstract: The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.
Source: Cancers
DOI: 10.3390/cancers12010062
Authors: Nikolaos Antoniou, Nefeli Lagopati, Dimitrios Ilias Balourdas, Michail Nikolaou, Alexandros Papalampros, Panagiotis V. S. Vasileiou, Vassilios Myrianthopoulos, Athanassios Kotsinas, Yosef Shiloh, Michalis Liontos, Vassilis G. Gorgoulis
Institutions: National and Kapodistrian University of Athens, General-Maternity District Hospital Helena Venizelou, Tel Aviv University, Alexandra Hospital, Manchester Academic Health Science Centre, University of Manchester, Biomedical Research Foundation of the Academy of Athens
Language: English
Open Access status: gold
Estimated APC paid: $1,824
OpenAlex ID: W2996955708
FWCI: 0.246
Cites: 98
Cited by: 28
Related to: 10