Work

A dual-action peptide-containing hydrogel targets wound infection and inflammation

Year: 2020

Type: article

Abstract: and reduced concentrations of proinflammatory cytokines. Proteolytic fragmentation of TCP-25 in vitro yielded a series of bioactive TCP fragments that were identical or similar to those present in wounds in vivo. Together, the results demonstrate the therapeutic potential of TCP-25 hydrogel, a wound treatment based on the body's peptide defense, for prevention of both bacterial infection and the accompanying inflammation.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aax6601

Authors: Manoj Puthia, Marta Butrym, Jitka Petrlova, Ann-Charlotte Strömdahl, Madelene Å. Andersson, Sven Kjellström, Artur Schmidtchen

Institutions: Lund University, Medicon Village, University of Copenhagen, Bispebjerg Hospital, Skåne University Hospital

Language: English

Topic: Wound Healing and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Stiftelsen för Strategisk Forskning, VINNOVA, Lunds Universitet, Knut och Alice Wallenbergs Stiftelse, Novo Nordisk, Vetenskapsrådet, Alfred Österlunds Stiftelse, Edvard Welanders Stiftelse, Novo Nordisk Fonden

Awards: G1933854042, Identifiering av nya behandlingsprinciper vid infektioner, TCP-25 gel for prevention of wound infection and inflammation – A proof of concept study, Fighting infection and inflammation by utilizing innate immunity, G4437986204, Peptide for reduction of infection and inflammation, Fighting infection and inflammation by utilizing innate immunity, G712881263

OpenAlex ID: W2997036886

FWCI: 21.59

Cites: 59

Cited by: 186

Related to: 10