Year: 2019
Type: article
Abstract: Automated segmentation of the aging brain raises significant challenges because of the prevalence, extent, and heterogeneity of white matter hyperintensities. White matter hyperintensities can be frequently identified in magnetic resonance imaging (MRI) scans of older individuals and among those who have Alzheimer's disease. We propose OASIS-AD, a method for automatic segmentation of white matter hyperintensities in older adults using structural brain MRIs. OASIS-AD is an approach evolved from OASIS, which was developed for automatic lesion segmentation in multiple sclerosis. OASIS-AD is a major refinement of OASIS that takes into account the specific challenges raised by white matter hyperintensities in Alzheimer's disease. In particular, OASIS-AD combines three processing steps: 1) using an eroding procedure on the skull stripped mask; 2) adding a nearest neighbor feature construction approach; and 3) applying a Gaussian filter to refine segmentation results, creating a novel process for WMH detection in aging population. We show that OASIS-AD performs better than existing automatic white matter hyperintensity segmentation approaches.
Source: NeuroImage Clinical
Language: English
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,600
Awards: G1058046096, G1834332590, The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's Disease, G236216809, Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology, Cardiovascular and HIV/AIDS Effects on Brain Structure/Function and Cognition, NIA Core Center to Build Neurodegenerative Disease Research Faculty At Penn, Statistical methods to improve reproducibility and reduce technical variability in heterogeneous multimodal neuroimaging studies of Alzheimer’s Disease, G3880778400, A Statistical Framework for the Spectral Analysis of High-Dimensional Physiological Time Series Signals, G707218699, G9000208814, G9000300274, G9000331231, Alzheimer Disease Research Center, Statistical Methods for Multilevel Multivariate Functional Studies
OpenAlex ID: W2997179245