Work

LED enhances anti-inflammatory effect of luteolin (3',4',5,7-tetrahydroxyflavone) in vitro.

Year: 2018

Type: article

Abstract: Neuroinflammation is a complex pathological process usually results from abnormal microglial activation, thus, intervention in a microglial stimulation pathway could be a promising approach for the treatment of neurodegenerative diseases. Luteolin is an important bioflavonoid possesses anti-inflammatory properties, which is widely studied over these years. Light emitting diode (LED) therapy is reported to be a potential therapeutic strategy for many diseases including neurodegenerative diseases. However, little is known about the anti-inflammatory effect of LED therapy on activated microglial cells, even less is known whether there is a synergistic anti-inflammatory effect exist in LED and luteolin therapy. In this study, we aimed to confirm the anti-inflammatory effect of luteolin and LED combination therapy in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. We showed that luteolin inhibited LPS-induced cytotoxicity, tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) production through modulation of p38 and extracellular signal-regulated kinase (ERK) signaling in BV2 cells. In addition, LED therapy enhanced the anti-inflammatory effect of luteolin. These results suggest that a synergistic effect between luteolin and LED could be a new effective therapy in relieving neuroinflammation.

Source: PubMed

Authors: Shengnuo Fan, Ahsan Habib, Jun Liu, Jun Tan

Institutions: Sun Yat-sen University, University of South Florida, Sun Yat-sen Memorial Hospital

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Center for Complementary and Integrative Health

Awards: Identification of novel APP-specific alpha secretase in human umbilical cord blood sera, A flavonoid gamma-secretase modulator (GSM) reduces beta-amyloid and tau pathologies in the AD mice, LISPRO, an ionic cocrystal of lithium, as a potential novel treatment for Alzheimer's disease, Flavonoid-diosmin modulation of Abeta and tau pathologies through GSK-3 signaling