Work

Ion Mobility Mass Spectrometry as an Efficient Tool for Identification of Streptorubin B in Streptomyces coelicolor M145

Year: 2020

Type: article

Abstract: Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B ( 2 ) as the natural product produced by Streptomyces coelicolor . Natural product 2 was initially assigned as butylcycloheptylprodigiosin ( 3 ), and only relatively recently was this assignment clarified. We present additional evidence of this assignment by comparing collisional cross sections (Ω) of synthetic standards of 2, 3, and metacycloprodigiosin ( 4 ) to the cyclic prodiginine produced by S. coelicolor . Calculated theoretical Ω values demonstrate that cyclic prodiginines could be identified without standards. This work highlights ion mobility as an efficient tool for the dereplication of natural products.

Source: Journal of Natural Products

DOI: 10.1021/acs.jnatprod.9b00828

Authors: Andrew P. Marshall, Andrew R. Johnson, Marvin M. Vega, Regan J. Thomson, Erin E. Carlson

Institutions: University of Minnesota, Indiana University Bloomington, Indiana University, Northwestern University

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green