Work

Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth through an Aspartate Aminotransferase-Independent Pathway

Year: 2020

Type: article

Abstract: Toxoplasma gondii is an obligate intracellular protozoan parasite and a successful parasitic pathogen in diverse organisms and host cell types. Hydroxylamine (HYD) and carboxymethoxylamine (CAR) have been reported as inhibitors of aspartate aminotransferases (AATs) and interfere with the proliferation in Plasmodium falciparum . Therefore, AATs are suggested as drug targets against Plasmodium . The T. gondii genome encodes only one predicted AAT in both T. gondii type I strain RH and type II strain PLK.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01889-19