Work

Cryo-EM cools down swine fever

Year: 2020

Type: article

Abstract: African swine fever virus (ASFV) is among the most complex DNA viruses known. Outbreaks have killed millions of swine around the world, and there is currently no vaccine. Three recent papers report the cryo-EM structure of the complete ASFV virion, comprising a viral particle of multiple layers, and resolve the major outer-capsid protein p72 to higher resolution. Progress in these reports provides a further understanding of the structure-function relationships of large viruses and should aid in ASFV vaccine development.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.h119.012169

Authors: John R. Gallagher, Audray K. Harris

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Animal Disease Management and Epidemiology

Subfield: Agronomy and Crop Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430