Relevant effects of Taohong Siwu decoctionon isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway
Year: 2019
Type: article
Abstract: Using rat thoracic aortic rings to test the relaxing effects of the 95% ethanol extract and aqueous extract of Taohong Siwu decoction (THSW) on endothelium intact or endothelium removed aortic rings. Results showed that the 95% ethanol extract (0.1, 1, 10, 100, 1000 mg·L-1 ) and aqueous extract (0.1, 1, 10, 100, 1000 mg·L-1 ) of THSW were able to relax the intact endothelium aortic rings pre-contracted by 10-6 mol·L-1 PE. 10-4 mol·L-1 L-NAME and 10-5 mol·L-1 methylene blue both were able to inhibit the relaxation other than indomethacin. For the endothelium removed aortic rings, potassium channel blocker 3×10-3mol·L-1 tetraethylammonium chloride and 10-5 mol·L-1 glibenclamide had no effect on the relaxation effects caused by the 95% ethanol extract and aqueous extract of THSW. It could be concluded that the 95% ethanol extract and aqueous extract of THSW relax blood vessel by endothelium-dependent way.
Authors: Qi Wu, Wanlong Zhao, Gangling Chen, Xue Su, Rong Li
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7162448523