Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites
Year: 2020
Type: article
Abstract: Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.
Source: Biomaterials Science
DOI: 10.1039/c9bm01029g
Institutions: Centre National de la Recherche Scientifique, Sorbonne Université, Chimie de la Matière Condensée de Paris, Inserm, École Pratique des Hautes Études, Université Paris Sciences et Lettres, Immunologie intégrative des tumeurs et immunothérapie du cancer, École Normale Supérieure - PSL, Laboratoire des Biomolécules, École Polytechnique, Laboratoire d'Optique et Biosciences, Institut Polytechnique de Paris
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2997843571