Year: 2020
Type: article
Abstract: Human functional brain connectivity is usually measured either at "rest" or during cognitive tasks, ignoring life's moments of mental transition. We propose a different approach to understanding brain network transitions. We applied a novel independent component analysis of functional connectivity during motor inhibition (stop signal task) and during the continuous transition to an immediately ensuing rest. A functional network reconfiguration process emerged that: (i) was most prominent in those without familial alcoholism risk, (ii) encompassed brain areas engaged by the task, yet (iii) appeared only transiently after task cessation. The pattern was not present in a pre-task rest scan or in the remaining minutes of post-task rest. Finally, this transient network reconfiguration related to a key behavioral trait of addiction risk: reward delay discounting. These novel findings illustrate how dynamic brain functional reconfiguration during normally unstudied periods of cognitive transition might reflect addiction vulnerability, and potentially other forms of brain dysfunction.
Source: NeuroImage
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,000
Awards: Statistical models for multi-modal brain imaging studies of HIV-associated cognitive decline, Alcohol-seeking behaviors and dopaminergic function, Brain reward responses to sweet tastes in alcoholism risk, Integrative Bioinformatics Approaches to Human Brain Genomics and Connectomics, Neural bases of alcohol-related decision-making, Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol
OpenAlex ID: W2997872467