Work

MicroRNA-1301 inhibits proliferation of human glioma cells by directly targeting N-Ras.

Year: 2017

Type: article

Abstract: studies revealed that increased levels of miR-1301-3p delayed the growth of intracranial tumors, which was accompanied by decreased Ki67 and CD31 expression. Taken together, our results demonstrate that miR-1301-3p plays a significant role in inactivating the Ras signaling pathway through the inhibition of N-Ras, which may provide a novel therapeutic strategy for treatment of glioma and other Ras-driven cancers.

Source: PubMed

Authors: Tongle Zhi, Kuan Jiang, Chuanzhuo Zhang, Xiupeng Xu, Weining Wu, Er Nie, Tianfu Yu, Xu Zhou, Zhongyuan Bao, Xin Jin, Junxia Zhang, Yingyi Wang, Ning Liu

Institutions: Jiangsu Province Hospital, Nanjing University of Chinese Medicine, Nanjing University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2997879606

FWCI: 2.127

Cites: 48

Cited by: 42

Related to: 10