Reduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals
Year: 2019
Type: article
Study design: Observational Study
Abstract: Background Pulmonary dysfunction is associated with elevated risk of cognitive decline. However, the mechanism underlying this relationship has not been fully investigated. In this study, we investigate the relationships between pulmonary function, cerebral small vessel disease (CSVD) markers, cortical thickness, and the Mini-Mental Status Examination (MMSE) scores in cognitively normal individuals. Methods We used a cross-sectional study design. We identified 1924 patients who underwent pulmonary function testing, three-dimensional brain magnetic resonance imaging (MRI), and the MMSE. Pulmonary function was analyzed according to the quintiles of percentage predicted values (% pred) for forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV 1 ). Regarding CSVD markers, we visually rated white matter hyperintensities (WMH) and manually counted lacunes and microbleeds. Cortical thickness was measured by surface-based methods. Results Compared with the highest quintile of FVC, the lowest quintile of FVC (% pred) showed a higher risk of WMH (OR 1.98, 95% CI: 1.21–3.24) and lacunes (OR 1.86, 95% CI: 1.12–3.08). There were no associations between FVC or FEV 1 and cortical thickness. Low FVC, but not FEV 1 , was associated with low MMSE scores. Path analyses showed that WMH partially mediated the positive relationship between FVC (% pred) and MMSE score. Conclusions Our findings suggested that decreased pulmonary function was associated with increased CSVD burdens, which in turn wass associated with decreased cognition, even in cognitively normal subjects.
Source: NeuroImage Clinical
Institutions: Kangwon National University, Kangwon National University Hospital, Hanyang University Medical Center, Hanyang University, Samsung (South Korea), Samsung Medical Center, Sungkyunkwan University, Chonnam National University, Chonnam National University Hospital, Inje University, Gyeongsang National University, Inje University Haeundae Paik Hospital, Gyeongsang National University Changwon Hospital, Kyung Hee University, Kyung Hee University Medical Center, Myongji Hospital, Wake Forest University Health Sciences, Wake Forest University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,600
Funders: National Research Foundation, Ministry of Science, ICT and Future Planning, Ministry of Health and Welfare, Korea Institute of Science and Technology, National Research Foundation of Korea, Ministry of Science ICT and Future Planning, National Research Council of Science and Technology, National Institutes of Health, Centers for Disease Control and Prevention, Korea Centers for Disease Control and Prevention, National Institute on Aging
OpenAlex ID: W2997885127