Predictors of distant metastasis in acinic cell carcinoma of the parotid gland
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: AiCC is a primarily indolent disease process. Our aim with this study is to determine characteristics consistent with rapidly progressive AiCC of the parotid gland. AIM: To report on patients with metastatic lung disease from AiCC and potential correlative factors. METHODS: Single-institution retrospective review of patients treated at the University of Michigan between 2000 and 2017. Univariate analyses were performed. RESULTS: < 0.001). CONCLUSION: AiCC of the parotid gland is viewed as a low-grade neoplasm with good curative outcomes and low likelihood of metastasis. With metastasis, however, it does exhibit a tendency to spread to the lungs. These patients thereby comprise a unique and understudied patient population. In this retrospective study, factors that have been shown to be statistically significant in association with worse disease-free survival and overall survival include presence of gross facial nerve invasion, higher T-classification, and high-grade disease.
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2997893659