Infiltrating myeloid cells and angiogenesis during skeletal muscle regeneration : role of p38γ/δ MAPKs in macrophage-phenotype acquisition
Year: 2019
Type: dissertation
Abstract: I joined the lab of Dra. Pura Muñoz to study the capacity of self-repair of skeletal muscle after an acute injury. During this process many different cell types interact to coordinate and regulate muscle repair. During those years I worked to shed light in how inflammation contributes to regulate skeletal muscle regeneration. Concretely, I worked in the characterization of a new macrophage’s population, characterized by the upregulation of MHC2, which appear at last stages of the regenerative process. Those cells seem to be essential in this context. In this work, we could be able to characterize the transcriptomes of all muscle-infiltrating myeloid populations and attribute a key role to p38 g/d MAPKs in their phenotypical acquisition and function. In addition, my work has demonstrated that myeloid-lack of both MAPK kinases leads in impaired muscle regeneration. In addition, during this thesis I has been working in the study of angiogenesis, concretely, in deciphering how microvascular network is reconstructed during muscle regeneration
Authors: Martínez García, Antonio Antonio
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2998130962