Length of gestation and birth weight are associated with indices of combined kidney biomarkers in early childhood
Year: 2019
Type: article
Abstract: Infants born prematurely or with low birth weights are more susceptible to kidney dysfunction throughout their lives. Multiple proteins measured in urine are noninvasive biomarkers of subclinical kidney damage, but few studies have examined the joint effects of multiple biomarkers. We conducted an exploratory study of 103 children in the Programing Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) longitudinal birth cohort, and measured nine proteins selected a priori in banked spot urine samples collected at ages 4-6. The goal of our study was to explore the combined effects of kidney damage biomarkers previously associated with birth outcomes. To do this, we generated kidney biomarker indices using weighted quantile sum regression and assessed associations with length of gestation or birth weight. A decile increase in each kidney biomarker index was associated with 2-day shorter gestations (β = -2.0, 95% CI: -3.2, -0.9) and 59-gram lower birth weights (β = -58.5, 95% CI: -98.3, -18.7), respectively. Weights highlighting the contributions showed neutrophil gelatinase-associated lipocalin (NGAL) (60%) and osteopontin (19%) contributed most to the index derived for gestational age. NGAL (66%) and beta-2-microglobulin (10%) contributed most to the index derived for birth weight. Joint analyses of multiple kidney biomarkers can provide integrated measures of kidney dysfunction and improved statistical assessments compared to biomarkers assessed individually. Additionally, shorter gestations and lower birth weights may contribute to subclinical kidney damage measurable in childhood.
Source: PLoS ONE
Authors: Yuri Levin-Schwartz, Paul Curtin, Katherine Svensson, Nicolas F. Fernandez, Seunghee Kim-Schulze, Gleicy M. Hair, Daniel Flores, Ivan Pantic, Marcela Tamayo-Ortiz, María Luisa Pizano-Zárate, Chris Gennings, Lisa M. Satlin, Andrea A. Baccarelli, Martha M. Tellez-Rojo, Robert O. Wright, Alison P. Sanders
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,595
Awards: Environment, Fetal Tissue DNA Methylation & Birthweight, Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal Health, The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) Cohort, Pittsburgh Center for Kidney Research, BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood Obesity, Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal Health, Stress-Air Pollution Interactions and Adolescent Neurobehavior, Research Training Program in Pediatric Exposomics, Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)
OpenAlex ID: W2998164049