Work

Author response: The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

Year: 2019

Type: peer-review

Abstract: The ORMDL proteins function to restrain the de novo sphingolipid biosynthetic pathway during myelination, when there is a high demand for sphingolipids to prevent excessive accumulation of metabolic intermediates.

Source: eLife

DOI: 10.7554/elife.51067.sa2

Authors: Benjamin A Clarke, Saurav Majumder, Hongling Zhu, Y Terry Lee, Mari Kono, Cuiling Li, Caroline Khanna, Hailey Blain, Ronit Schwartz, Vienna L Huso, Colleen Byrnes, Galina Tuymetova, Teresa M Dunn, Maria L Allende, Richard L Proia

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Uniformed Services University of the Health Sciences

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: University of South Carolina, Fondation Leducq, National Institutes of Health, Hollings Cancer Center, Medical University of South Carolina, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1410469566, G4796340452, COBRE in Lipidomics and Pathobiology, G9000204985, Medical University of South Carolina - Cancer Center Support Grant

OpenAlex ID: W2998318876

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