Work

ORP5 regulates PI(4)P on the lipid droplet: Novel players on the monolayer

Year: 2019

Type: article

Abstract: How the distinct lipid composition of organelles is determined and maintained is still poorly understood. In this issue, Du et al. (2019. J. Cell Biol.https://doi.org/10.1083/jcb.201905162) show that the lipid transfer protein ORP5 functions at ER-LD contact sites, regulating lipid droplet levels of phosphatidylserine and phosphatidylinositol-4-phosphate.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201912010

Authors: Mike F. Renne, Brooke M. Emerling

Institutions: University of Oxford, Sanford Burnham Prebys Medical Discovery Institute

Language: English

Topic: Lipid metabolism and biosynthesis

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: U.S. Department of Defense

Award: TARGETING THE NONCANONICAL PHOSPHOINOSITIDE KINASES IN P53-MUTANT BREAST CANCER