Cerebellum-specific deletion of the GABA A receptor δ subunit alters anxiety-like, social and maternal behaviors without affecting motor performance
Year: 2019
Type: preprint
Abstract: GABA A receptors containing the δGABA A subunit (δGABA A Rs) are involved in many physiological and pathophysiological processes, such as sleep, pain, stress, anxiety-related behaviors, and postpartum depression. These extrasynaptically located, high affinity and slowly desensitizing receptors mediate tonic inhibition throughout the brain, including in granule cells (GCs) of the cerebellar input layer. However, the extent to which δGABA A Rs control the excitability of the cerebellar input layer and ultimately regulate behavior is unknown. We therefore deleted δGABA A subunits specifically from GCs and determined the behavioral consequences in mice. Deletion reduced tonic inhibition and increased input layer excitability, but remarkably, did not affect either locomotion or motor learning. Unexpectedly, δGABA A deletion heightened anxiety-like behaviors, and caused female-specific alterations in social and maternal behavior. Our findings establish that the cerebellar input layer is critical for regulating diverse behaviors that are relevant to psychiatric and neurodevelopmental disorders but were previously not associated with the cerebellum.
Institution: Harvard University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2998716854