Work

Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got?

Year: 2009

Type: article

Abstract: With the advancement of vectors, delivery methods, and newly identified molecular targets, preclinical studies have shown that gene transfer is effective in improving left ventricular contractility and attenuating deleterious left ventricular remodeling in myocardial infarction-associated congestive heart failure (CHF). We are optimistic that these favorable effects will also be seen when tested in patients with CHF associated with myocardial infarction, as well as in patients with CHF from other etiologies. Gene therapy has the potential to be tailored to meet the needs of individual patients. Moreover, when used in conjunction with pharmacological and device management of the patient with CHF, it provides hope for a brighter future for the 23 million patients worldwide with this devastating disease.

Source: PubMed

Authors: H Kirk Hammond, Tong Tang

Institutions: University of California San Diego, VA San Diego Healthcare System

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Awards: Mechanisms of Adenylyl Cyclase Effects in the Heart, Translational Studies of AAV Gene Transfer for CHF, Discovery and Development of Therapeutic Genes for CHF