Work

Single-Center Use of Prothrombin Complex Concentrate in Pediatric Patients

Year: 2020

Type: article

Abstract: Coagulation disturbances frequently occur in critically ill children. Four-factor prothrombin complex concentrate (4F-PCC) may have a potential role in managing these patients while avoiding concerns associated with fresh frozen plasma. However, data on this product in critically ill children is scarce. We retrospectively identified 24 critically ill pediatric patients who received 4F-PCC. The primary indication was to correct coagulopathy and control bleeding in the trauma or surgical setting. 4F-PCC effectively decreased the international normalized ratio level, a surrogate marker of hemostasis. Further study is warranted to identify efficacy, indications, optimal dosing, and adverse effects in the critically ill pediatric patients.

Source: Journal of Pediatric Intensive Care

DOI: 10.1055/s-0039-1700953

Authors: Takaharu Karube, Courtney Andersen, Joseph D. Tobias

Institutions: Nationwide Children's Hospital, Ohio University, The Ohio State University

Language: English

Topic: Trauma, Hemostasis, Coagulopathy, Resuscitation

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2999116454

FWCI: 0.951

Cites: 28

Cited by: 14

Related to: 10