Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins
Year: 2020
Type: article
Abstract: While the GAS M protein has been the leading vaccine target for decades, the bacteria encode many other virulence factors of interest for vaccine development. In this work, we show that emm -like genes are encoded in a remarkable majority of GAS genomes and expressed at a level similar to that for the emm gene. In collaboration with the U.S. Centers for Disease Control, we developed molecular definitions of the different emm and emm -like gene families. This clarification should abrogate mistyping of strains, especially in the area of whole-genome typing. We have also updated the emm -typing collection by removing emm -like gene sequences and provided in-depth analysis of Mrp and Enn protein sequence structure and diversity.
Source: mSphere
Institutions: Université Libre de Bruxelles, The University of Melbourne, Peter Doherty Institute, University of Wollongong, Illawarra Health and Medical Research Institute, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Murdoch Children's Research Institute, The University of Queensland, Queen Fabiola Children's University Hospital
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,500
Award: G5145456306
OpenAlex ID: W2999154355