Work

Towards computer-aided design of cellular structure

Year: 2020

Type: article

Abstract: Cells are complex machines with tremendous potential for applications in medicine and biotechnology. Although much effort has been devoted to engineering the metabolic, genetic, and signaling pathways of cells, methods for systematically engineering the physical structure of cells are less developed. Here we consider how coarse-grained models for cellular geometry at the organelle level can be used to build computer-aided design (CAD) tools for cellular structure.

Source: Physical Biology

DOI: 10.1088/1478-3975/ab6d43

Authors: Simone Bianco, Yee-Hung Mark Chan, Wallace F Marshall

Institutions: IBM Research - Almaden, San Francisco State University, University of California, San Francisco

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: National Science Foundation

Award: Center for cellular construction