Work

Retargeting adenoviruses for therapeutic applications and vaccines

Year: 2020

Type: review

Abstract: Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in their in vitro and in vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It discusses that true vector targeting involves not only retargeting viruses, but importantly also detargeting the viruses from off-target cells.

Source: FEBS Letters

DOI: 10.1002/1873-3468.13731

Authors: Michael A. Barry, Jeffrey D. Rubin, Shao‐Chia Lu

Institution: Mayo Clinic

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Congressionally Directed Medical Research Programs