Multidimensional correlation spectroscopic imaging of exponential decays: From theoretical principles to in vivo human applications
Year: 2020
Type: article
Abstract: Multiexponential modeling of relaxation or diffusion MR signal decays is a popular approach for estimating and spatially mapping different microstructural tissue compartments. While this approach can be quite powerful, it is also limited by the fact that one-dimensional multiexponential modeling is an ill-posed inverse problem with substantial ambiguities. In this article, we present an overview of a recent multidimensional correlation spectroscopic imaging approach to this problem. This approach helps to alleviate ill-posedness by making advantageous use of multidimensional contrast encoding (e.g., 2D diffusion-relaxation encoding or 2D relaxation-relaxation encoding) combined with a regularized spatial-spectral estimation procedure. Theoretical calculations, simulations, and experimental results are used to illustrate the benefits of this approach relative to classical methods. In addition, we demonstrate an initial proof-of-principle application of this kind of approach to in vivo human MRI experiments.
Source: NMR in Biomedicine
DOI: 10.1002/nbm.4244
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, University of Southern California, National Institutes of Health, Alfred E. Mann Institute for Biomedical Engineering, University of Southern California, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1066422085, CAREER: Low-Rank Matrix Modeling for Constrained Reconstruction from Noisy and Sparsely-Sampled Data, G1600216079, G3048631115, G3075044527, Faster MRI with Sparse Sampling and Low-Rank Modeling, Longitudinal evaluation of cardiosphere-derived cell regenerative treatment onmyocardial fiber architecture using diffusion tensor cardiac magnetic resonance for dilatedcardiomyopathy, G9000024958, G9000050521, G9000156017, Next generation in-vivo diffusion imaging at submillimeter resolution
OpenAlex ID: W2999564328