Liver‐on‐a‐Chip Models of Fatty Liver Disease
Year: 2020
Type: review
Abstract: As a consequence of the obesity epidemic and increasing incidence of metabolic syndrome fatty liver disease now affects a large portion of the world’s population. Left untreated, fatty liver disease can progress to more severe pathologic conditions such as cirrhosis and liver cancer. In an effort to probe the pathophysiology of fatty liver disease and its progression, research over the last decade has led to the engineering of in vitro models of the liver to aid in drug discovery and study of liver pathophysiology. In this review, we discuss advances in modeling liver tissue and the latest developments in understanding disease etiology and treatment from the perspective of engineered in vitro models spanning from conventional planar, static monolayer cultures to those based on the more recently developed bioprinted and liver-on-a-chip platforms. These technologies promise to transform basic biological research, the pharmaceutical industry, and clinical medicine of the liver.
Source: Hepatology
DOI: 10.1002/hep.31106
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer Therapy, High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized Organoids, Ischemia-reperfusion injury in liver transplantation, Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor Models
OpenAlex ID: W2999601492