Work

Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC

Year: 2020

Type: article

Abstract: Hydroxylation is a post-translational modification affecting protein stability, activity or interactome. We identified adenylosuccinate lyase (ADSL) as a novel hydroxylation substrate in triple negative breast cancer. Hydroxylation affects ADSL enzymatic activity and, therefore, adenosine levels. Adenosine, in turn, favors the translation of cMYC, triggering its oncogenic downstream cascade.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2019.1707045

Authors: Giada Zurlo, Qing Zhang

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Cancer Prevention and Research Institute of Texas, National Cancer Institute