Work

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping

Year: 2020

Type: article

Abstract: locus indicates that PRC1-anchored loops are versatile architectural platforms that persist when surrounding genes are transcriptionally active and fine-tune their expression. The analysis of RING1B binding profiles and 3D contacts during neural differentiation in mice suggests that this role is conserved in mammals.

Source: Science Advances

DOI: 10.1126/sciadv.aax4001

Authors: V. Loubiere, G. L. Papadopoulos, Q. Szabo, A-M. Martinez, G. Cavalli

Institutions: Centre National de la Recherche Scientifique, Université de Montpellier, Institut de Génétique Humaine

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

Funders: Agence Nationale de la Recherche, European Research Council, H2020 European Research Council