Work

Neurodegeneration in Narcolepsy‐Associated Rapid Eye Movement Sleep Behavior Disorder

Year: 2020

Type: article

Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with increased muscle tone during REM sleep. 1 It strongly marks neurodegenerative synucleinopathies, including Parkinson's disease and dementia with Lewy bodies. 2 Many narcolepsy patients have RBD symptoms.3 It has been suggested that the pathophysiology of RBD in narcolepsy differs from idiopathic RBD, perhaps being related to the instability of sleep stages.Moreover, patients with narcolepsy show fewer degenerative disease signs.4 This would imply that narcolepsy-RBD should not be associated with neurodegenerative disease.Here we report a patient with narcolepsy who developed neurodegenerative synucleinopathy, albeit with characteristics that seemed to suggest 2 independent pathophysiologies.

Source: Movement Disorders Clinical Practice

DOI: 10.1002/mdc3.12895

Authors: Seyed Ali Naeimi, Jacques Y. Montplaisir, Jean‐Francois Gagnon, Ronald B. Postuma

Institutions: Montreal General Hospital, McGill University, Hôpital du Sacré-Cœur de Montréal, Canadian Sleep & Circadian Network, Université de Montréal, Université du Québec à Montréal

Language: English

Topic: Sleep and Wakefulness Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3000104658

FWCI: 0.248

Cites: 10

Cited by: 3

Related to: 10