Work

A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions

Year: 2020

Type: article

Abstract: A ball-milling-enabled zinc-mediated Barbier-type allylation reaction is reported. Notably, running the reaction in this manner renders it effective irrespective of the initial morphology of the zinc metal. The process is operationally simple, does not require inert atmospheres or dry solvents, and is reported over a range of aldehyde and ketone substrates; a gram-scale process is demonstrated.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.9b02876

Authors: JieXiang Yin, Roderick T. Stark, Ian A. Fallis, Duncan L. Browne

Institution: Cardiff University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green