Year: 2020
Type: article
Abstract: BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. METHODS: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). RESULTS: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. CONCLUSIONS: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
Source: Breast Cancer Research
Authors: Alicia K. Heath, David C. Muller, Piet A. van den Brandt, Nikos Papadimitriou, Elena Critselis, Marc Gunter, Paolo Vineis, Elisabete Weiderpass, Guy Fagherazzi, Heiner Boeing, Pietro Ferrari, Anja Olsen, Anne Tjønneland, Patrick Arveux, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Tilman Kühn, Renée Turzanski-Fortner, Matthias B. Schulze, Anna Karakatsani, Paschalis Thriskos, Antonia Trichopoulou, Giovanna Masala, Paolo Contiero, Fulvio Ricceri, Salvatore Panico, Bas Bueno-de-Mesquita, Marije F. Bakker, Carla H. van Gils, Karina Standahl Olsen, Guri Skeie, Cristina Lasheras, Antonio Agudo, Miguel Rodríguez-Barranco, Maria-José Sánchez, Pilar Amiano, María-Dolores Chirlaque, Aurelio Barricarte, Isabel Drake, Ulrika Ericson, Ingegerd Johansson, Anna Winkvist, Tim Key, Heinz Freisling, Mathilde His, Inge Huybrechts, Sofia Christakoudi, Merete Ellingjord-Dale, Elio Riboli, Konstantinos K. Tsilidis, Ioanna Tzoulaki
Institutions: Imperial College London, Maastricht University Medical Centre, University of Ioannina, Centre international de recherche sur le cancer, Harokopio University of Athens, Biomedical Research Foundation of the Academy of Athens, Inserm, Luxembourg Institute of Health, Centre de recherche en Epidémiologie et Santé des Populations, German Institute of Human Nutrition, Danish Cancer Society, University of Copenhagen, Centre Georges François Leclerc, German Cancer Research Center, University of Potsdam, National and Kapodistrian University of Athens, Hellenic Health Foundation, University General Hospital Attikon, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Turin, Federico II University Hospital, University of Naples Federico II, University Medical Center Utrecht, University of Malaya, National Institute for Public Health and the Environment, Utrecht University, UiT The Arctic University of Norway, Universidad de Oviedo, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Biogipuzkoa Health Research Institute, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Lund University, Umeå University, University of Gothenburg, University of Oxford, King's College London
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,380
Funders: World Health Organization, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, World Cancer Research Fund International, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ministerie van Volksgezondheid, Welzijn en Sport, Ligue Contre le Cancer, Vetenskapsrådet, Consiglio Nazionale delle Ricerche, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Wereld Kanker Onderzoek Fonds, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
Awards: G104449235, G1055973116, G1075502044, G1192877484, G1344656563, G1478484880, G172151099, G1767199718, G1788645866, G1993546569, G2027148636, G2149865848, G2216207056, G2235605558, G2257231888, G2293058991, G2372467518, G2539064604, G273148272, G2841678936, G2871896171, G29072894, G2933204024, G2999139090, G3010599472, G3049845011, G3077395769, G3084320185, G3189789075, G3217467674, G3350062835, G3452641779, G3544161537, G3675143906, G3747421453, G375319704, G3980646122, G4041385912, G4049848471, G4081633361, G4089957676, G4187108342, G4213141252, G43956866, G4473162978, Health of vegetarians, G459595259, G4682079261, G4811780622, G4884057766, G490534113, G5004963360, G5288121262, G558017500, G5706284561, G5747748742, G5897142711, G5990830295, G6085534252, NIHR Senior Investigator Award, G6594529311, G6779186093, G6820515600, G7025202487, G7040807446, G7306252069, G7426181285, G7447125227, G7600088736, G7624991799, G7646326732, G7939399614, G8050896463, G817390530, G8407261631, G8500560359, G8508326818, G8869854444, G8978728421
OpenAlex ID: W3000219461