PO-116 Increase in prothymosin alpha expression with histological aggressiveness of glioma
Year: 2018
Type: conference-abstract
Abstract: Introduction Gliomas are the most common primary brain tumours accounting for 2.5% of the total cancer deaths worldwide. c-Myc is a proto-oncogene, it plays an important role in initiation and progression of gliomas. It upregulates expression of nuclear onco-protein prothymosin alpha (PTMA). PTMA is a transcription factor with a spectrum of functions ranging from cell cycle regulator to immunomodulatory function depending upon its distribution. Its overexpression is reported in malignancies of breast, liver, lung and bladder. Material and methods This study was conducted on patients who underwent elective surgery for glioma (n=176). The histological grading and MIB1 labelling index was recorded from surgical pathology reports. Expression levels of PTMA in these tissues were assessed by immunohistochemistry. Results and discussions Our study population consisted of 30 (17%) Grade I, 56 (31.8%) Grade II, 45 (25.6%) Grade III and 45 (25.6%) Grade IV glioma cases. PTMA expression was significantly associated with the histological grades of glioma (p Conclusion Our study demonstrates the involvement of PTMA overexpression in the pathogenesis of glioma and its association with histological grading and proliferation. Differential expression of this protein suggests its potential utility in histological grading and prognosis of glioma.
Source: ESMO Open
Authors: P. Aathreya, A. Kumar
Institution: All India Institute of Medical Sciences
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,910
OpenAlex ID: W3000237116