Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression
Year: 2019
Type: article
Abstract: Background: We hypothesized that the risk of colorectal cancer in night-shift workers might be different according to insulin receptor substrate status. Methods: Among 77,470 eligible women having night work assessed in the Nurses' Health Study, we documented a total of 1,397 colorectal cancer cases, of which 304 or 308 had available data on IRS1 and IRS2, respectively. We used duplication-method Cox proportional hazards regression analysis for competing risks to calculate HRs and 95% confidence intervals (CI) for each colorectal cancer subtype. We measured tumor IRS1 or IRS2 expression by immunohistochemistry (IHC). Results: Compared with women who never worked night shifts, those working ≥15 years night shifts had a marginal trend of increased overall risk of colorectal cancer (Ptrend = 0.06; multivariable HR = 1.20; 95% CI, 0.99–1.45). Longer duration of night-shift work was associated with a higher risk of IRS2-positive tumors (multivariable HR = 2.69; 95% CI, 1.48–4.89; Ptrend = 0.001, ≥15 years night shifts vs. never) but not with IRS2-negative tumors (multivariable HR = 0.90; 95% CI, 0.54–1.51; Ptrend = 0.72; Pheterogeneity for IRS2 = 0.008). Similarly, the corresponding multivariable HRs were 1.81 for IRS1-positive tumors (95% CI, 0.94–3.48; Ptrend = 0.06) and 1.13 for IRS1-negative tumors (95% CI, 0.71–1.80; Ptrend = 0.56; Pheterogeneity for IRS1 = 0.02). Conclusions: Our molecular pathologic epidemiology data suggest a potential role of IRS in mediating carcinogenesis induced by night-shift work. Impact: Although these findings need validation, rotating night shift might increase colorectal cancer risk in women with abnormal insulin receptor pathways.
Authors: Yan Shi, Li Liu, Tsuyoshi Hamada, Jonathan A. Nowak, Marios Giannakis, Yanan Ma, Mingyang Song, Daniel Nevo, Keisuke Kosumi, Mancang Gu, Sun A. Kim, Teppei Morikawa, Kana Wu, Jing Sui, Kyriaki Papantoniou, Molin Wang, Andrew T. Chan, Charles S. Fuchs, Jeffrey A. Meyerhardt, Edward Giovannucci, Shuji Ogino, Eva S. Schernhammer, Reiko Nishihara, Xuehong Zhang
Institutions: Harvard University, Chinese PLA General Hospital, Dana-Farber Cancer Institute, Huazhong University of Science and Technology, Brigham and Women's Hospital, Broad Institute, Dana-Farber/Harvard Cancer Center, Massachusetts Institute of Technology, China Medical University, Massachusetts General Hospital, National Institutes of Health, National Cancer Institute, The University of Tokyo, Southeast University, Medical University of Vienna, Yale Cancer Center, Yale University, Smilow Cancer Hospital
Language: English
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, Calcium and Colorectal Cancer: Gene-Environment Interactions and Molecular Pathways, G1858048302, Epigenetic Events and Colorectal Cancer Epidemiology, Inflammation and Colorectal Neoplasia, Accelerating Transdisciplinary Epidemiology of Colorectal Cancer, G3383927743, Dietary and Hormonal Determinants of Cancer in Women, Impact of Celecoxib and Inflammation on Survival in Stage III Colon Cancer, Mentored Patient-Oriented Research in Digestive Diseases, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Lifestyle, genetics and colonoscopy for colorectal cancer prevention, Calcium Intake and Colorectal Cancer Incidence and Survival, Precision Prevention Research Program
OpenAlex ID: W3000284801