Work

Circulating cell-free DNA: Translating prostate cancer genomics into clinical care

Year: 2020

Type: review

Abstract: Only in the past decade tremendous advances have been made in understanding prostate cancer genomics and consequently in applying new treatment strategies. As options regarding treatments are increasing so are the challenges in selecting the right treatment option for each patient and not the least, understanding the optimal time-point and sequence of applying available treatments. Critically, without reliable methods that enable sequential monitoring of evolving genotypes in individual patients, we will never reach effective personalised driven treatment approaches. This review focuses on the clinical implications of prostate cancer genomics and the potential of cfDNA in facilitating treatment management.

Source: Molecular Aspects of Medicine

DOI: 10.1016/j.mam.2019.100837

Authors: Delila Gasi Tandefelt, Johann de Bono

Institutions: Sahlgrenska University Hospital, University of Gothenburg, Royal Marsden NHS Foundation Trust, Institute of Cancer Research

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,150