Year: 2020
Type: review
Abstract: Cerebral edema, a common and often fatal companion to most forms of acute central nervous system disease, has been recognized since the time of ancient Egypt. Unfortunately, our therapeutic armamentarium remains limited, in part due to historic limitations in our understanding of cerebral edema pathophysiology. Recent advancements have led to a number of clinical trials for novel therapeutics that could fundamentally alter the treatment of cerebral edema. In this review, we discuss these agents, their targets, and the data supporting their use, with a focus on agents that have progressed to clinical trials.
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Metabolomic predictors of stroke in REGARDS, G2145263961, G261343034, G4479290998, G46503767, Astrocyte regulation of the blood-brain barrier in intracerebral hemorrhage, G6230834768, The Recovery in Stroke Using PAP (RISE UP) Study, G7833360837, Yale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)
OpenAlex ID: W3000514028