Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization
Year: 2020
Type: review
Abstract: Macrophage activation and polarization are closely linked with metabolic rewiring, which is required to sustain their biological functions. These metabolic alterations allow the macrophages to adapt to the microenvironment changes associated with inflammation or tissue damage (hypoxia, nutrient imbalance, oxidative stress, etc.) and to fulfill their highly energy-demanding proinflammatory and anti-microbial functions. This response is integrated via metabolic sensors that coordinate these metabolic fluxes with their functional requirements. Here we review how the metabolic and phenotypic plasticity of macrophages are intrinsically connected with the hypoxia stress sensors and the unfolded protein response in the endoplasmic reticulum, and how these molecular pathways participate in the maladaptive polarization of macrophages in human pathology and chronic inflammation.
Source: Frontiers in Immunology
Institution: Hospital Universitario Central de Asturias
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: G1075404386, G1647210306, G1771215323, G3891908349, G3946622174, G3991268419, G4193446334, G4333900429, MODULACIÓN EPIGENÉTICA DE LA TOLERANCIA INMUNOLÓGICA. DESARROLLO DE NUEVOS ABORDAJES TERAPÉUTICOS EN EL TRASPLANTE RENAL., G7448866147, Regulación epigenética de los procesos inflamatorios asociados al daño renal crónico. Identificación de nuevas dianas terapéuticas, CARACTERIZACION DE UN MAPA DE ALTA RESOLUCION DEL INFILTRADO INMUNE EN EL DAÑO RENAL Y TRASPLANTE. MODULACION EPIGENÉTICA CON NANOPARTICULAS., G895413899
OpenAlex ID: W3000622012