Year: 2020
Type: review
Abstract: The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation of which are vital for healthy bodily function. The timing of many physiological processes, including glucose metabolism, are coordinated by the circadian system, and circadian disruptions that desynchronise or misalign these rhythms can result in adverse health outcomes. In this review, we cover the role of the circadian system and its disruption in glucose metabolism in healthy individuals and individuals with type 2 diabetes mellitus. We begin by defining circadian rhythms and circadian disruption and then we provide an overview of circadian regulation of glucose metabolism. We next discuss the impact of circadian disruptions on glucose control and type 2 diabetes. Given the concurrent high prevalence of type 2 diabetes and circadian disruption, understanding the mechanisms underlying the impact of circadian disruption on glucose metabolism may aid in improving glycaemic control.
Source: Diabetologia
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,480
Awards: Meal Time Effects on Metabolic Health., Role of Meal Timing in Efficacy of Bariatric Surgery in Obese Individuals, Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes Risk, The Harvard Clinical and Translational Science Center, Development of countermeasures against adverse metabolic effects of shift work, Training Program in Hypertension, Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 Diabetes, Aldosterone and Cardiovascular Disease: Research and Mentoring Program, Training in Sleep, Circadian, and Respiratory Neurobiology
OpenAlex ID: W3000654447