Parahydrogen‐Induced Hyperpolarization of Gases
Year: 2020
Type: article
Abstract: Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen-induced polarization is a fast, highly scalable, and low-cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen-induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.
Authors: Kirill V. Kovtunov, Igor V. Koptyug, Marianna Fekete, Simon B. Duckett, Thomas Theis, Baptiste Joalland, Eduard Y. Chekmenev
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: Oak Ridge Associated Universities, Wellcome Trust, Edward Mallinckrodt, Jr. Foundation, Russian Foundation for Basic Research, Russian Science Foundation, Directorate for Mathematical and Physical Sciences, Medical Research Council, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, DOD Peer Reviewed Cancer Research Program
Awards: G1860239242, G2548589564, A National Centre for Translational Hyperpolarised Magnetic Resonance, G2937977385, G333190983, Centre for Hyperpolarisation in MRI., G4828815178, G6105720164, Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in Cancer, G6991488888, Hyperpolarisation using SABRE as a new tool for imaging., G7510719559
OpenAlex ID: W3000758534