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The Value of Twins for Health and Medical Research: A Third of a Century of Progress

Year: 2020
Type: review
Abstract: In 1984, Hrubec and Robinette published what was arguably the first review of the role of twins in medical research. The authors acknowledged a growing distinction between two categories of twin studies: those aimed at assessing genetic contributions to disease and those aimed at assessing environmental contributions while controlling for genetic variation. They concluded with a brief section on recently founded twin registries that had begun to provide unprecedented access to twins for medical research. Here we offer an overview of the twin research that, in our estimation, best represents the field has progress since 1984. We start by summarizing what we know about twinning. We then focus on the value of twin study designs to differentiate between genetic and environmental influences on health and on emerging applications of twins in multiple areas of medical research. We finish by describing how twin registries and networks are accelerating twin research worldwide.
DOI: 10.1017/thg.2020.4
Institutions: Royal Children's Hospital, Deakin University, Murdoch Children's Research Institute, Ministry of Education, The University of Melbourne, Coordenação de Aperfeicoamento de Pessoal de Nível Superior, Royal Women's Hospital, Washington State University Spokane
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $525
Funders: Children’s Hospital of Wisconsin Research Institute, Murdoch Children's Research Institute, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, State Government of Victoria, Ministério da Educação, Medical Research Council, National Health and Medical Research Council
OpenAlex ID: W3000909579
FWCI: 1.145
Cites: 81
Cited by: 43
Related to: 10