Work

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

Year: 2018

Type: article

Abstract: MKs. Altogether, these data show that ablating PITPs in MKs indirectly dysregulates hematopoiesis in the BM by disrupting α-granule physiology and secretion of TGF-β1.

Source: Blood

DOI: 10.1182/blood-2017-09-806257

Authors: Maegan Capitano, Liang Zhao, Scott Cooper, Chelsea Thorsheim, Aae Suzuki, Xinxin Huang, Alexander L. Dent, Michael S. Marks, Charles S. Abrams, Hal E. Broxmeyer

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1087124759, Mechanisms of Synergistic Regulation of Stem/Progenitors, G1359627168, Regulation of Platelet and Endothelial Cell Function, Regulation of Hematopoietic Cell Production, Enhancing Engraftment of Cord Blood by CD26 Inhibition, Platelet granule formation and function in health and disease, Platelet signals and their interface with the external environment, Controlling Influences of Oxygen Tension and CD26/DPP4 Enzymatic Activity on Regulation of Hematopoietic Stem/Progenitor Cells and Hematopoiesis During Health, Ageing, and Disease, G9000067707, G9000111846, G9000304140, G9000326640, Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy

OpenAlex ID: W2883926892

FWCI: 1.059

Cites: 38

Cited by: 19

Related to: 10