Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis
Year: 2020
Type: article
Study design: Observational Study
Abstract: Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60-80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites associated with BMD and osteoporosis. In peripheral blood monocytes, dihydropyrimidine dehydrogenase, an enzyme essential to D-BAIBA generation, exhibited positive association with physical activity and hip BMD. Along with their signaling roles, BAIBA and GABA might serve as biomarkers for diagnosis and treatments of osteoporosis.
Source: Communications Biology
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,290
Funders: U.S. Department of Health and Human Services, Tulane University, National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1033827860, G1285708275, G131902472, Regulation of Store-Operated Calcium Entry During Muscle Aging, G19956286, Integration of fMRI imaging, genomics, network and biological knowledge, G2846649503, Integration of brain imaging with genomic and epigenomic data, OSTEOCYTE REGULATION OF BONE/MUSCLE WITH AGING, Epigenomewide DNA Methylation Study for Osteoporosis Risk, Decoding Methylation Mediated Epigenomic Contributions to Male Osteoporosis, Integration of multiscale genomic data for comprehensive analysis of complex dise, G5553974194, G571018580, G6943722246, G7643228873, Loss of Numb in Muscle Dysfunction in Aging, G9000206401, G9000270380, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases, Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions, Trans-omics Integration of Multi-omics Studies for Osteoporosis
OpenAlex ID: W3001329756