Work

Necrotizing Fasciitis: Pillaging the Acute Phase Response

Year: 2020

Type: review

Abstract: ➤ Necrotizing fasciitis hijacks the acute phase response, increasing the risk of developing pathophysiologic states commonly associated with death: sepsis-induced coagulopathy (SIC), systemic inflammatory response syndrome (SIRS), and adrenal insufficiency, referred to as critical illness-related corticosteroid insufficiency (CIRCI). ➤ Dynamic monitoring of SIC, SIRS, and CIRCI may be informative when assessing infection severity and when directing treatment to manage these conditions as soon as they begin to develop. ➤ To reduce the risk of oropharyngeal colonization, N95 respirators should be worn by health-care professionals who are operating on patients with necrotizing fasciitis.

Source: Journal of Bone and Joint Surgery

DOI: 10.2106/jbjs.19.00591