Work

Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations

Year: 2020

Type: review

Abstract: In spite of current treatment strategies, myocardial infarction and stroke are still major causes of death worldwide. These events are triggered by damage of an atherosclerotic plaque, resulting in occlusive thrombus formation. Mouse studies have significantly contributed to our understanding of the mechanisms of atherogenesis and of thrombosis following plaque injury, but the extent to which the mouse serves as an accurate model of human disease is open to discussion. In this review, we provide a detailed overview and comparison of the described mouse models for atherothrombosis including their (dis)advantages. Herein guidance is provided on how to select a suitable atherothrombosis model for research questions primarily relevant to the field of thrombosis.

Source: Platelets

DOI: 10.1080/09537104.2019.1708884

Authors: MFA Karel, B. Hechler, MJE Kuijpers, JMEM Cosemans

Institutions: Maastricht University, Inserm, Établissement Français du Sang, Biologie et pharmacologie des plaquettes sanguines : hémostase, thrombose, transfusion, Université de Strasbourg

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,970