Year: 2020
Type: review
Abstract: Disturbances of the immune system and immune responses after activation are a common finding in neuropsychiatric disorders. Psychotic and affective disorders such as major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BD) also share high rates of comorbidity with inflammatory and metabolic disorders. Evidence of elevated circulating inflammatory cytokines, altered numbers and function of immune cells, and evidence of neuroinflammation including activation of microglia in the brain have been found in patients with SCZ, BD and MDD. Often these findings correlate to psychological state at the time of measurement. However, significant variation exists across these studies in many aspects, creating challenges in identifying a specific signature of immune dysfunction in these disorders. Innate immune dysfunction, and alterations in monocytes, the critical sentinel cells of the innate immune system, have been seen repeatedly in all three of these disorders, with frequent overlap in findings. In this review, dysfunction specific to the innate arm of the immune system is compared for overlapping evidence across three major psychotic and affective disorders.
Authors: H.K. Hughes, P. Ashwood
Institution: University of California, Davis
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,250
Funders: National Science Foundation, Brain and Behavior Research Foundation, National Alliance for Research on Schizophrenia and Depression, National Institutes of Health, National Institute of Mental Health, National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Immune regulation and neurodevelopmental disorders, Maternal asthma and brain development, MIND Institute Intellectual and Developmental Disabilities Research Center, Immune regulation and autism, THE CHARGE STUDY: CHILDHOOD AUTISM RISKS FROM GENETICS AND THE ENVIRONMENT, Graduate Research Fellowship Program (GRFP), The UC Davis Center for Children's Enviromental Health and Disease Prevention, G7448323819, The effects of environmental air pollutants on maternal allergic asthma and its neurobiological consequences, Immune regulation and gastrointestinal co-morbidity in autism spectrum disorders, UC Davis Environmental Health Sciences Core Center
OpenAlex ID: W3002085994