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Antibiotic resistance: turning evolutionary principles into clinical reality

Year: 2020
Type: article
Abstract: Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The past few decades have witnessed rapid progress in our understanding of the multiple factors that affect the emergence and spread of antibiotic resistance at the population level and the level of the individual patient. However, the process of translating this progress into health policy and clinical practice has been slow. Here, we attempt to consolidate current knowledge about the evolution and ecology of antibiotic resistance into a roadmap for future research as well as clinical and environmental control of antibiotic resistance. At the population level, we examine emergence, transmission and dissemination of antibiotic resistance, and at the patient level, we examine adaptation involving bacterial physiology and host resilience. Finally, we describe new approaches and technologies for improving diagnosis and treatment and minimizing the spread of resistance.
DOI: 10.1093/femsre/fuaa001
Authors: Dan I Andersson, Nathalie Q Balaban, Fernando Baquero, Patrice Courvalin, Philippe Glaser, Uri Gophna, Roy Kishony, Søren Molin, Tone Tønjum
Institutions: Uppsala University, Hebrew University of Jerusalem, Institut Pasteur, Tel Aviv University, Technion – Israel Institute of Technology, Novo Nordisk Foundation, Technical University of Denmark, Oslo University Hospital, University of Oslo
Language: English
Open Access status: green
OpenAlex ID: W3002094434
FWCI: 19.14
Cites: 194
Cited by: 238
Related to: 10